Reactive oxygen species ( ROS ) and IRF 1 stimulate IFN α production by 1 proximal tubules during ischemic AKI
نویسندگان
چکیده
Reactive oxygen species (ROS) and IRF1 stimulate IFNα production by 1 proximal tubules during ischemic AKI. 2 Pamela D. Winterberg, Yanxia Wang, Keng-Mean Lin, John R. Hartono, Glenn T. Nagami, Xin J. Zhou, 3 John M. Shelton, James A. Richardson, and Christopher Y. Lu . 4 5 Author Contributions: PDW and YW contributed equally to the majority of experimental data presented; PDW 6 participated in the writing of the manuscript; JRH assisted in CD45-bead isolation experiments; KML performed 7 the assays of PKTPS stimulation by α-IFNs versus β-IFN; GTN contributed the S3 murine renal tubular cell 8 line; XJZ evaluated and scored histologic sections; JMS and JAR performed the in situ hybridizations, CYL 9 supervised the planning and interpretation of the experiments, and the writing of the manuscript. 10 Affiliations: From the Departments of Pediatrics (Nephrology Division) (1), Internal Medicine [Nephrology 11 Division (2), and Cardiology Division (3)], Pathology (4), and Graduate School of Biomedical Sciences 12 (Immunology) (5), UT Southwestern Medical Center, Dallas, TX; Nephrology Section, VA Greater Los Angeles 13 and University of California, Los Angeles, Los Angeles, CA (5). 14 Running head (60 character limit): ROSand IRF1-induced IFNα during ischemic AKI (37 characters) 15 16 Corresponding author: Christopher Y. Lu, M.D. Dept. Internal Medicine (Nephrology Division), UT 17 Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8856. FAX 214-648-2071, phone 21418 648-3959/ email: [email protected] 19 20 Articles in PresS. Am J Physiol Renal Physiol (May 8, 2013). doi:10.1152/ajprenal.00487.2012
منابع مشابه
Reactive oxygen species and IRF1 stimulate IFNα production by proximal tubules during ischemic AKI.
We previously reported that expression of the transcription factor interferon regulatory factor 1 (IRF1) is an early, critical maladaptive signal expressed by renal tubules during murine ischemic acute kidney injury (AKI). We now show that IRF1 mediates signals from reactive oxygen species (ROS) generated during ischemic AKI and that these signals ultimately result in production of α-subtypes o...
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Pamela D. Winterberg, Yanxia Wang, Keng-Mean Lin, John R. Hartono, Glenn T. Nagami, Xin J. Zhou, John M. Shelton, James A. Richardson, and Christopher Y. Lu Department of Pediatrics, Nephrology Division, University of Texas Southwestern Medical Center, Dallas, Texas; Department of Internal Medicine, Nephrology Division, University of Texas Southwestern Medical Center, Dallas, Texas; Department ...
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